The Miller Lab
  • Meet The Team
  • Publications
  • Presentations
  • Posts
  • Software
  • Funding
  • Donate
Categories
All (54)
2002 (1)
2004 (1)
2007 (1)
2008 (4)
2010 (1)
2016 (4)
2017 (2)
2018 (2)
2019 (2)
2020 (7)
2021 (14)
2022 (9)
2023 (6)
BCC (4)
CSCC (11)
Clinical Informatics (5)
Ipi/Nivo (1)
Melanoma (13)
Merkel Cell Carcinoma (18)
NLP (1)
Neoadjuvant (2)
Nivo/Rela (1)
R (5)
REDCap (4)
Regulatory Medicine (2)
Squamous Cell Carcinoma (1)

Publications

Skin Cancer Chemoprevention for Transplant Recipients - The Search Continues

2023
CSCC

In this Perspectives on the Science piece, we reflect on the impact of the recently published ONTRANS trial.

Mar 22, 2023
48 min

Surgical Factors Affecting Regionally Metastatic Cutaneous Squamous Cell Carcinoma to the Parotid Gland

2023
CSCC

Understanding the impact of surgical treatment on regionally metastatic cutaneous squamous cell carcinoma (cSCC) is important as treatment paradigms shift with the introduction of immune checkpoint inhibitors. Herein, we aim to describe surgical impact on outcomes for regionally metastatic cSCC

Feb 12, 2023
0 min

Lacking Overall IMspiration for Triplet Therapy in Melanoma? A Review of the Interim Analysis of IMspire150.

2023
Melanoma

In this Perspectives on the Science piece, we reflect on the impact of the recently published article by Ascierto et al. in Lancet Oncology that provides interim results from IMspire150.

Feb 4, 2023
49 min

Targeting TBK1 to overcome resistance to cancer immunotherapy

2023

We demonstrate that targeting TBK1 is a novel and effective strategy to overcome resistance to cancer immunotherapy.

Jan 11, 2023
0 min

Therapy with oncolytic viruses: progress and challenges

2023

We review the available data and provide guidance on optimizing the use of oncolytic viruses in clinical practice.

Jan 10, 2023
0 min

Tumor-Infiltrating Lymphocyte Therapy for Advanced Melanoma: Ready for Prime Time?

2023
Melanoma

In this Perspectives on the Science piece, published in the Journal of Cutaneous Oncology, we reflect on the impact of the recently published article “Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma”.

Jan 9, 2023
28 min

Neoadjuvant Nivo/Rela for Resectable Melanoma

2022
Melanoma
Neoadjuvant
Nivo/Rela

In this Perspectives on the Science piece, published in the Journal of Cutaneous Oncology, we reflect on the impact of the recently published article “Neoadjuvant relatlimab and nivolumab in resectable melanoma”.

Dec 5, 2022
38 min

Ipi/Nivo for Advanced MCC

2022
Merkel Cell Carcinoma
Ipi/Nivo

In this Perspectives on the Science piece, published in the Journal of Cutaneous Oncology, we reflect on the impact of the recently published article “Combined Nivolumab and Ipilimumab with or without Stereotactic Body Radiation Therapy for Advanced Merkel cell carcinoma - A Randomised, Open Label, Phase 2 Trial”.

Nov 21, 2022
9 min

Neoadjuvant ICI for Resectable CSCC

2022
Squamous Cell Carcinoma
Neoadjuvant

In this Perspectives on the Science piece, published in the Journal of Cutaneous Oncology we reflect on the impact of the recently published article Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma.

Nov 8, 2022
5 min

Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network

2022

We present the results of a clinical pilot to standardize precision oncology workflows. This was published in The Oncologist in November 2022.

Nov 2, 2022
0 min

Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

2022
CSCC

We present a prosepective study of neoadjuvant cemiplimab in high-risk resectable CSCC. This study was published in the New England Journal of Medicine in September 2022.

Sep 11, 2022
0 min

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of nonmelanoma skin cancer

2022
Merkel Cell Carcinoma
BCC
CSCC

Society guidelines for the management of NMSC. Published in the Journal for ImmunoTherapy of Cancer, July 2022.

Jul 27, 2022
1 min

A Retrospective Study of Ipilimumab Plus Nivolumab in Anti-PD-L1/PD-1 Refractory Merkel Cell Carcinoma

2022
Merkel Cell Carcinoma

We present a dual-institution retrospective study of Ipi/Nivo in refractory MCC. This was published in The Journal of Immunotherapy, July 2022.

Jul 27, 2022
1 min

Immunotherapy for Nonmelanoma Skin Cancer: Facts and Hopes

2022
CSCC
BCC
Merkel Cell Carcinoma

We review the latest trends in cancer care for Nonmelanoma skin cancer. Published in Clinical Cancer Research, June 2022.

May 31, 2022
0 min

StoryboardR - An R Package and Shiny Application Designed to Visualize Real-World Data From Clinical Patient Registries

2022
Clinical Informatics
R
REDCap

We created StoryboardR, an R package and Shiny application facilitates the data visualization of real-world data from tumor registries captured in REDCap®.

Feb 23, 2022
28 min

Generalizable EHR-R-REDCap Pipeline for a National Multi-Institutional Rare Tumor Patient Registry

2021
Merkel Cell Carcinoma
Clinical Informatics
REDCap
R

We present a clinical informatics pipeline designed to capture large-scale structured laboratory EHR data.

Dec 18, 2021
21 min

BodyMapR - An R Package and Shiny Application Designed to Generate Anatomical Visualizations of Cancer Lesions

2021
Merkel Cell Carcinoma
Clinical Informatics
R

R package for enhanced visualizations of cancer lesions

Dec 10, 2021
67 min

Impact of an Evolving Regulatory Landscape on Skin Cancer Drug Development in the U.S

2021
Merkel Cell Carcinoma
CSCC
BCC
Regulatory Medicine
Melanoma

We present an analysis of the impact of an evolving regulatory landscape on skin cancer drug development.

Nov 13, 2021
131 min

Assessing Changes in Clinical Perineural Invasion during Immunotherapy for Head and Neck Cutaneous Squamous Cell Carcinoma

2021
CSCC

We report on the clinical experience of treating with immunotherapy for head and neck Cutaneous Squamous Cell Carcinoma.

Nov 10, 2021
0 min

The Merkel Cell Carcinoma Patient Registry-From Promise to Prototype to Patient

2021
Merkel Cell Carcinoma
REDCap

We present a white paper outlining the objectives and applications of the Merkel Cell Carcinoma Patient Registry.

Nov 9, 2021
17 min

GENETEX - A GENomics Report TEXt Mining R Package and Shiny Application Designed to Capture Real-World Clinico-Genomic Data

2021
Merkel Cell Carcinoma
Clinical Informatics
R
NLP

We created GENETEX, an R package and Shiny application for text mining genomic reports from EHR and direct import into REDCap®.

Sep 27, 2021
27 min

Diagnostic yield of staging brain magnetic resonance imaging is low in Merkel cell carcinoma - A single-institution cohort study

2021
Merkel Cell Carcinoma
Journal: Journal of the American Academy of Dermatology (preprint). Accepted September 6, 2021. Please see the postprint on the JAAD Website.
Sep 5, 2021
6 min

Clinical Utility of Cell-free DNA Liquid Biopsies in Merkel Cell Carcinoma

2021
Merkel Cell Carcinoma

An examination of the clinical utility of liquid biopsies in Merkel Cell Carcinoma.

Aug 30, 2021
16 min

Immunotherapy for Non-Melanoma Skin Cancer

2021
CSCC
BCC
Merkel Cell Carcinoma

We review the latest trends in cancer care for Non-Melanoma skin cancer.

Aug 26, 2021
0 min

Evaluation of clinical characteristics and pre-biopsy impressions of primary Merkel cell carcinoma of the skin

2021
Merkel Cell Carcinoma
Journal: D…
Aug 19, 2021
6 min

Immune Checkpoint Inhibition in Marjolin Ulcer - A Case Series

2021
CSCC

We provide a case series in the Journal of Immunotherapy of response to anti-PD1 therapy in Marjolin Ulcer.

Jun 19, 2021
0 min

Commentary on Surgical Margins in MCC

2021
Merkel Cell Carcinoma
We provide commentary on a recent publication in…
Apr 6, 2021
0 min

Microsatellitosis in Merkel cell carcinoma - a staging quandary

2021
Merkel Cell Carcinoma

We provide an analysis in the Dermatology Online Journal of microsatellitosis in a cohort of MCC patients.

Mar 14, 2021
0 min

Real-world assessment of response to anti-PD1 therapy in advanced cutaneous squamous cell carcinoma

2021
CSCC

In the JAAD, we provide a real-world assessment of response to anti-PD1 therapy in advanced cutaneous squamous cell carcinoma.

Jan 14, 2021
0 min

A REDCap-Based Operational Tool to Guide Care Coordination in a Multidisciplinary Cutaneous Oncology Clinic

2020
Clinical Informatics
REDCap
R
We’re excited to share our recently published manuscript at JCO OP describing a REDCap-Based Operational Tool to Guide Care Coordination in a Multidisciplinary Cutaneous…
Nov 12, 2020
1 min

Clinical landscape of oncolytic virus research in 2020

2020

We provide an overview of the clinical landscap of oncolytic virus research.

Oct 7, 2020
1 min

Metastatic Merkel Cell Carcinoma Masquerading as multiple immune-related Adverse Events

2020
Merkel Cell Carcinoma

We present a case of MCC masquerading as Multiple Immune-Related Adverse Events

Sep 29, 2020
0 min

Regionally Metastatic Merkel Cell Carcinoma Associated with Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis

2020
Merkel Cell Carcinoma

We present a case of MCC presenting with NMDA Receptor Encephalitis.

Sep 25, 2020
0 min

TdT Expression Is a Marker of Better Survival in Merkel Cell Carcinoma, and Expression of B-Cell Markers Is Associated With Merkel Cell Polyomavirus

2020
Merkel Cell Carcinoma

TdT expression is a potential marker of better survival in Merkel cell carcinoma.

Jun 7, 2020
1 min

Evaluation of the fragility of pivotal trials used to support FDA approval for plaque psoriasis

2020
Regulatory Medicine

We evaluate the fragility of pivotal trials used to support FDA approval in Plaque Psoriasis.

Apr 6, 2020
28 min

Generalized Acquired Cutis Laxa Associated with Monoclonal Gammopathy of Dermatological Significance

2020

We present a case of Acquired Cutis Laxa associated with Monocloncal Gammopathy of Monoclonal Significance.

Feb 12, 2020
1 min

Inhibition of Haspin kinase promotes cell-intrinsic and extrinsic anti-tumor activity

2019
Melanoma

Inhibition of Haspin kinase may overcome drug resistance in melanoma, modulate the immune environment and target a vulnerability in different cancer lineages.

Dec 28, 2019
0 min

Clinical spectrum of cutaneous melanoma morphology.

2019
Melanoma
BACKGROUND: Melanoma can mimic other cutaneous lesions, but the full spectrum and prevalence of these morphologic variants remain largely unknown.
OBJECTIVE: To classify nonacral cutaneous melanomas into distinct morphologic clusters and characterize clusters’…


Dec 31, 2018
1 min

Kaposi’s varicelliform eruption in a patient with metastatic melanoma and primary cutaneous anaplastic large cell lymphoma treated with talimogene laherparepvec and nivolumab

2018
Melanoma

We present a case of Eczema Tvecium secondary to T-Vec

Oct 31, 2018
1 min

High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma

2018
Melanoma
Cutaneous melanoma is an aggressive tumor that accounts for most skin cancer deaths. Among the physiological barriers against therapeutic success is a strong survival…
Jun 30, 2018
0 min

A Complete Response in cSCC with Ipi/Nivo

2017
CSCC
Although most cases of metastatic cutaneous Squamous Cell Carcinoma mCSCC can be cured with local therapy, up to 8,000 deaths occur each year. With no US Food and Drug…
Sep 7, 2017
0 min

Somatic Driver Mutations in Melanoma

2017
Melanoma
Somatic driver mutations in melanoma.
May 18, 2017
0 min

A novel multi-CDK inhibitor P1446A-05 restricts melanoma growth and produces synergistic effects in combination with MAPK pathway inhibitors

2016
Melanoma

We present a novel multi-CDK inhibitor that restricts melanoma growth

Jul 1, 2016
0 min

Molecularly Targeted Therapies and Immunotherapies For Melanoma

2016
Melanoma
Current status and future directions of molecularly targeted therapies and immunotherapies for melanoma.
May 31, 2016
0 min

CDKs as Therapeutic Targets in Melanoma

2016
Melanoma
Cyclin-dependent kinases as therapeutic targets in melanoma. Miller and Flaherty (2014)
May 16, 2016
0 min

Molecular testing in melanoma

2016
Melanoma

We present an overview of the role of molecular testing in melanoma

Apr 30, 2016
0 min

Parameters for Establishing Humanized Mouse Models

2010
Parameters for establishing…
Mar 31, 2010
0 min

TLR Activation Abrogates Mixed Chimerism

2008
TLR agonists abrogate co-stimulation blockade-induced mixed chimerism and transplantation tolerance.
Nov 30, 2008
0 min

Viral infection - a potent barrier to transplantation tolerance

2008
Viral infection: a potent barrier to transplantation tolerance.
Jun 25, 2008
0 min

TLR Agonists Abrogate Immunological Tolerance

2008
TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Apr 30, 2008
0 min

Role of Innate Immunity in Transplantation Tolerance

2008
Role of Innate Immunity in Transplantation Tolerance.
Mar 31, 2008
0 min

Different mechanisms control peripheral and central tolerance

2007
Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice. Yamazaki et al. (2007)
Jun 8, 2007
0 min

Jellypin - a lower eukaryotic serine proteinase inhibitor (serpin)

2004
Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin. Cole et al. (2004)
Sep 20, 2004
0 min

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases

2002
The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.
Mar 4, 2002
0 min
No matching items