Clinical & Translational Investigators in Skin Cancer

Ongoing Projects, Research and Efforts

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All MCC Registry Clinical Trials Data Science Biomarkers Clinical Educator Real World Data Regulatory Medicine

Clinical Educator

Participating in the education of tomorrow’s clinicians

Real World Data Analysis

Optimizing Real World Data Collection

Clinical Trials for Skin Cancer

Investigating novel therapies for patients with advanced skin cancer

Biomarkers of Response and Resistance to Cancer Therapy

Investigating why patients do or do not respond to cancer therapies

Data Science Tool Development

Developing Data Science tools to facilitate clinical and translational research

Evolving Landscape of Regulatory Medicine

Evaluating the evolving landscape of regulatory medicine in Cutaneous Oncology and Dermatology

Merkel Cell Carcinoma Patient Registry

Developing a multi-institutional Patient Registry.

Meet the Team

Principal Investigator

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David Michael Miller

Medical Oncologist and Dermatologist

Clinical And Translational Research, Advanced Skin Cancer, Data Science, R

Fellows

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Sophia Shalhout

Cutaneous Oncology Research Fellow

Clinical and Biomedical Informatics, Immuno-oncology/Cutaneous Oncology, R/Data Science

Students

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Farees Saqlain

Medical Student

Clinical And Translational Research, Merkel Cell Carcinoma, Squamous Cell Carcinoma

Researchers

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Kayla Wright

Clinical Research Assistant

Biomedical Research, Photography

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Matthew Miller

Clinical Research Assistant

Biomedical Research

Publications

Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network

We present the results of a clinical pilot to standardize precision oncology workflows.
DOI

Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

We present a prosepective study of neoadjuvant cemiplimab in high-risk resectable CSCC.
Gross, Neil D., David Michael Miller, Khushalani, Nikhil I., Divi, Vasu, Ruiz, Emily S., Lipson, Evan J., Meier, Friedegund, Su, Yungpo B., Swiecicki, Paul L., Atlas, Jennifer, Geiger, Jessica L., Hauschild, Axel, Choe, Jennifer H., Hughes, Brett G.M., Schadendorf, Dirk, Patel, Vishal A., Homsi, Jade, Taube, Janis M., Lim, Annette M., Ferrarotto, Renata, Kaufman, Howard L., Seebach, Frank, Lowy, Israel, Yoo, Suk-Young and Mathias, Melissa and Fenech, Keilah and Han, Hyunsil and Fury, Matthew G. and, Rischin, Danny
Source Document DOI

A Retrospective Study of Ipilimumab Plus Nivolumab in Anti-PD-L1/PD-1 Refractory Merkel Cell Carcinoma

We present a retrospective study of Ipi/Nivo in refractory MCC.
Source Document DOI

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of nonmelanoma skin cancer

Society guidelines for the management of NMSC.
PDF Source Document DOI

StoryboardR - An R Package and Shiny Application Designed to Visualize Real-World Data From Clinical Patient Registries

We created StoryboardR, an R package and Shiny application facilitates the data visualization of real-world data from tumor registries …
Code Project Project Video

Generalizable EHR-R-REDCap Pipeline for a National Multi-Institutional Rare Tumor Patient Registry

We present a clinical informatics pipeline designed to capture large-scale structured laboratory EHR data.
Project Project DOI

BodyMapR - An R Package and Shiny Application Designed to Generate Anatomical Visualizations of Cancer Lesions

We present BodyMapR, an R package & Shiny application that generates anatomical visualizations of cancer lesions from REDCap.
Code Project Source Document DOI

Impact of an Evolving Regulatory Landscape on Skin Cancer Drug Development in the U.S

We present an analysis of the impact of an evolving regulatory landscape on skin cancer drug development.
Project

Assessing Changes in Clinical Perineural Invasion during Immunotherapy for Head and Neck Cutaneous Squamous Cell Carcinoma

We report on the clinical experience of treating with immunotherapy for head and neck Cutaneous Squamous Cell Carcinoma.
DOI

The Merkel Cell Carcinoma Patient Registry-From Promise to Prototype to Patient

We present a white paper outlining the objectives and applications of the Merkel Cell Carcinoma Patient Registry.
Project Project

Diagnostic yield of staging brain magnetic resonance imaging is low in Merkel cell carcinoma - A single-institution cohort study

In the JAAD, we provide a real-world assessment of the yield of diagnostic brain MRIs in Merkel Cell Carcinoma.
PDF Project Project Source Document DOI

GENETEX - A GENomics Report TEXt Mining R Package and Shiny Application Designed to Capture Real-World Clinico-Genomic Data

We created GENETEX, an R package and Shiny application for text mining genomic reports from EHR and direct import into REDCap®.
PDF Code Dataset Project Project Video Source Document

Clinical Utility of Cell-free DNA Liquid Biopsies in Merkel Cell Carcinoma

An examination of the clinical utility of liquid biopsies in Merkel Cell Carcinoma.
Project Project

Immunotherapy for Non-Melanoma Skin Cancer

We review the latest trends in cancer care for Non-Melanoma skin cancer.
PDF Project Project Source Document DOI

Evaluation of clinical characteristics and pre-biopsy impressions of primary Merkel cell carcinoma of the skin

A review of prebiopsy clinical DDx of primary cutaneous MCC lesions from a recent, single-institution 5 year cohort.
Project Project
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Recent & Upcoming Talks

Optimizing the Management of Patients With Advanced Non-Melanoma Skin Cancers in Community-Based Dermatology, Oncology, and Dermato-Oncology Practices

Nov 21, 2022 2:00 PM — 3:00 PM Online Forum
Slides Follow

Optimizing the Management of Patients With Advanced Non-Melanoma Skin Cancers in Community-Based Dermatology, Oncology, and Dermato-Oncology Practices

Nov 18, 2022 12:00 PM — 1:00 PM Online Forum
Slides Follow

Optimizing the Management of Patients With Advanced Non-Melanoma Skin Cancers in Community-Based Dermatology, Oncology, and Dermato-Oncology Practices

Nov 17, 2022 1:00 PM — 2:00 PM Online Forum
Slides Follow

Optimizing the Management of Patients With Advanced Non-Melanoma Skin Cancers in Community-Based Dermatology, Oncology, and Dermato-Oncology Practices

Nov 9, 2022 12:00 PM — 1:00 PM Online Forum
Slides Follow

Cutaneous Malignancies: How Would You Manage This Patient?

Nov 4, 2022 12:20 PM — 1:00 PM
Project Event Follow

Prognostic Gene Expression Profiling for Cutaneous Squamous Cell Carcinoma: Does it Add to Staging

Nov 4, 2022 12:10 PM — 12:20 PM
Project Event Follow

Cases in Basal Cell Carcinoma: Fostering Interdisciplinary Care

Pearls in the management of Basal Cell Carcinoma
Nov 4, 2022 10:30 AM — 11:30 AM
Event Follow

Optimizing the Management of Patients With Advanced Non-Melanoma Skin Cancers in Community-Based Dermatology, Oncology, and Dermato-Oncology Practices

Oct 26, 2022 12:00 PM — 1:00 PM Online Forum
Slides Follow

Practical Management Pearls for Immunotherapy for the Treatment of Nonmelanoma Skin Cancer

Oct 3, 2022 11:00 AM — 12:00 PM Online Forum
Slides Follow

Immunotherapeutic Strategies in Skin Cancer

Primer on Immunotherapeutic Strategies in Skin Cancer
Aug 17, 2022 7:45 AM — 8:45 AM Harvard Dermatology Online Forum
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Recent Posts

Perspectives on the Science: Ipi/Nivo for Advanced MCC

We provide a commentary on the recent Lancet Oncology article on Ipi/Nivo advanced MCC.
Last updated on Nov 27, 2022 9 min read

Perspectives on the Science: Neoadjuvant Cemiplimab for High-Risk CSCC

We provide a commentary on the recent NEJM article on neoadjuvant cemiplimab for advanced CSCC.
Last updated on Nov 19, 2022 6 min read

Optimizing Real-World Data Collection: The Lesion Information Electronic Data Capture Instrument

We publish the data dictionary for our Lesion Information data collection instrument
Last updated on Dec 9, 2021 111 min read

Data Quality Improvement in Cancer Registries- Error-Injection Tests

A proposed workflow for monitoring completion of retrospective records in a patient registry hosted on REDCap
Last updated on Jul 23, 2021 9 min read

Optimizing Real-World Data Collection: Genomics Electronic Data Capture Instrument

We publish the data dictionary for our genomics data collection instrument
Last updated on May 9, 2021 4645 min read

FlexDashboards for Clinical and Translational Research

A monograph on how to create Dashboards using R via a package called flexdashboard
Jan 5, 2021 24 min read

A REDCap-to-R Pipeline for Interactive Body Map Visualizations in Cutaneous Oncology

A data science tool for interactive visualizations of skin cancer lesions
Last updated on Sep 4, 2021 950 min read

Communicating CT Research via Website Development with R

This working document is a rough user guide on how to create a website using R via a package called blogdown
Dec 14, 2020 11 min read

Optimizing Real-World Data Collection: Clinical Genomics

Facilitate capture of real-world next-generation genomic data
Last updated on Jan 5, 2021 11 min read

Reference Management in RMarkdown

Integrate your EndNote library into RMarkdown
Last updated on May 9, 2021 4 min read
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Software

StoryboardR

A Shiny App to visualize the patient journey from registry data
Last updated on Nov 28, 2022

BodyMapR

A Shiny app that generates anatomical visualizations of cancer lesions from structured data
Last updated on Nov 27, 2022

FDA Approvals in Skin Cancer - A Shiny App

A Shiny App to visualize the FDA approved therapies for skin cancer
Last updated on Nov 27, 2022

GENETEX

A Shiny App to perform NLP on clinicogenomic data
Last updated on Nov 27, 2022

Generalizable EHR Labs Abstraction (eLAB) Pipeline

A pipeline to extract laboratory data from Epic and integrate into a structured research database
Last updated on Nov 27, 2022

Past and Current Funding

Project Data Sphere’s Mentoring Award in Oncology, Advanced Analytics and Regulatory Science

Merkel Cell Carcinoma Patient Registry
Last updated on Dec 12, 2019

ECOG ACRIN Paul Carbone, MD Fellowship Award

A Novel JAK1 Inhibitor to Overcome BRAF/MEK Inhibitor Resistance in V600-BRAF Mutant Melanoma
Last updated on Dec 12, 2019

American Skin Association Research Grant

JAK1 Inhibition to Overcome BRAF/MEK Inhibitor Resistance in V600-BRAF Mutant Melanoma
Last updated on Dec 12, 2019

American Diabetes Association Physician Scientist Training Award

Umbilical cord blood stem cells as therapy for Diabetes Mellitus
Last updated on Dec 12, 2019

Support Cancer Research

If you are interested in supporting our research please visit our Donation page at Massachusetts General Hospital by clicking here.

Contact

Clinical Matters:

For clinical questions, please contact the MGH Cancer Center
Telephone: 617-724-5197
Fax: 617-643-1740

Lab Related Matters

The below contact information is for The Miller Lab related matters

Email

  • 617-726-2667
  • 15 Parkman Street, Boston, MA, 02114, United States
  • Enter Bartlett Hall, to Basement, Room 132
  • DM Me