Clinical & Translational Investigators in Skin Cancer

Ongoing Projects, Research and Efforts

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All MCC Registry Clinical Trials Data Science Biomarkers Clinical Educator Real World Data Regulatory Medicine

Clinical Educator

Participating in the education of tomorrow’s clinicians

Real World Data Analysis

Optimizing Real World Data Collection

Clinical Trials for Skin Cancer

Investigating novel therapies for patients with advanced skin cancer

Biomarkers of Response and Resistance to Cancer Therapy

Investigating why patients do or do not respond to cancer therapies

Data Science Tool Development

Developing Data Science tools to facilitate clinical and translational research

Evolving Landscape of Regulatory Medicine

Evaluating the evolving landscape of regulatory medicine in Cutaneous Oncology and Dermatology

Merkel Cell Carcinoma Patient Registry

Developing a multi-institutional Patient Registry.

Meet the Team

Principal Investigator

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David Michael Miller

Medical Oncologist and Dermatologist

Clinical And Translational Research, Advanced Skin Cancer, Data Science, R

Fellows

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Sophia Shalhout

Cutaneous Oncology Research Fellow

Clinical and Biomedical Informatics, Immuno-oncology/Cutaneous Oncology, R/Data Science

Students

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Farees Saqlain

Medical Student

Clinical And Translational Research, Merkel Cell Carcinoma, Squamous Cell Carcinoma

Researchers

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Kayla Wright

Clinical Research Assistant

Biomedical Research, Photography

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Matthew Miller

Clinical Research Assistant

Biomedical Research

Publications

StoryboardR - An R Package and Shiny Application Designed to Visualize Real-World Data From Clinical Patient Registries

We created StoryboardR, an R package and Shiny application facilitates the data visualization of real-world data from tumor registries …
Code Project Project Video

Generalizable EHR-R-REDCap Pipeline for a National Multi-Institutional Rare Tumor Patient Registry

We present a clinical informatics pipeline designed to capture large-scale structured laboratory EHR data.
Project Project DOI

BodyMapR - An R Package and Shiny Application Designed to Generate Anatomical Visualizations of Cancer Lesions

We present BodyMapR, an R package & Shiny application that generates anatomical visualizations of cancer lesions from REDCap.
Code Project Source Document DOI

Impact of an Evolving Regulatory Landscape on Skin Cancer Drug Development in the U.S

We present an analysis of the impact of an evolving regulatory landscape on skin cancer drug development.
Project

Assessing Changes in Clinical Perineural Invasion during Immunotherapy for Head and Neck Cutaneous Squamous Cell Carcinoma

We report on the clinical experience of treating with immunotherapy for head and neck Cutaneous Squamous Cell Carcinoma.
DOI

The Merkel Cell Carcinoma Patient Registry-From Promise to Prototype to Patient

We present a white paper outlining the objectives and applications of the Merkel Cell Carcinoma Patient Registry.
Project Project

Diagnostic yield of staging brain magnetic resonance imaging is low in Merkel cell carcinoma - A single-institution cohort study

In the JAAD, we provide a real-world assessment of the yield of diagnostic brain MRIs in Merkel Cell Carcinoma.
PDF Project Project Source Document DOI

GENETEX - A GENomics Report TEXt Mining R Package and Shiny Application Designed to Capture Real-World Clinico-Genomic Data

We created GENETEX, an R package and Shiny application for text mining genomic reports from EHR and direct import into REDCap®.
PDF Code Dataset Project Project Video Source Document

Clinical Utility of Cell-free DNA Liquid Biopsies in Merkel Cell Carcinoma

An examination of the clinical utility of liquid biopsies in Merkel Cell Carcinoma.
Project Project

Immunotherapy for Non-Melanoma Skin Cancer

We review the latest trends in cancer care for Non-Melanoma skin cancer.
PDF Project Project Source Document DOI

Evaluation of clinical characteristics and pre-biopsy impressions of primary Merkel cell carcinoma of the skin

A review of prebiopsy clinical DDx of primary cutaneous MCC lesions from a recent, single-institution 5 year cohort.
Project Project

Immune Checkpoint Inhibition in Marjolin Ulcer - A Case Series

We provide a case series in the Journal of Immunotherapy of response to anti-PD1 therapy in Marjolin Ulcer.
Project Source Document DOI

Commentary on Surgical Margins in MCC

We provide commentary on a recent publication in JAMA Derm on margins in MCC.
Source Document

Microsatellitosis in Merkel cell carcinoma - a staging quandary

We provide an analysis in the Dermatology Online Journal of microsatellitosis in a cohort of MCC patients.
Project Source Document

Real-world assessment of response to anti-PD1 therapy in advanced cutaneous squamous cell carcinoma

In the JAAD, we provide a real-world assessment of response to anti-PD1 therapy in advanced cutaneous squamous cell carcinoma.
PDF Project Source Document DOI
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Recent & Upcoming Talks

mGODS - Monoclonal Gammopathies Of Dermatological Significance

Pearls for working up monclonal gammopathies in setting of dermatological disease
May 6, 2022 7:45 AM — 8:45 AM Massachusetts General Hospital Online Forum
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Merkel Cell Carcinoma: Current Concepts in Diagnosis and Management

Pearls in the management of Merkel Cell Carcinoma
Apr 30, 2022 9:30 AM — 9:50 AM
Event Follow

Basal Cell Carcinoma: How to Effectively Manage Your Patients

Pearls in the management of Basal Cell Carcinoma
Apr 30, 2022 9:10 AM — 9:30 AM
Event Follow

Diagnostic Yield of Staging Brain MRI in Merkel Cell Carcinoma

Real world evaluation of initial brain MRI in MCC
Apr 26, 2022 11:15 AM — 11:30 AM University of Washington School of Medicine
Project Event Follow

Real-world assessment of ipi-nivo in anti-PD-(L)-1 refractory Merkel Cell Carcinoma

Real world evaluation of ipilimumab/nivolumab in PD-1/PDL-1 refractory MCC
Apr 25, 2022 3:06 PM — 3:18 PM University of Washington School of Medicine
Project Event Follow

Seeing Nonmelanoma Skin Cancers Through a New Lens - The Role and Place of Immunotherapy

Pearls on the current concepts in diagnosis and management of NMSC
Apr 22, 2022 2:30 PM — 3:30 PM European Association of Dermato Oncology
Project Event Follow

Merkel Cell Carcinoma - Current Concepts in Diagnosis and Management

Pearls on the current concepts in diagnosis and management of MCC
Mar 28, 2022 9:30 AM — 10:00 AM American Academy of Dermatology Annual Meeting
Project Event Follow

Real-world assessment of ipi-nivo in anti-PD-(L)-1 refractory Merkel Cell Carcinoma

Real world evaluation of ipilimumab/nivolumab in PD-1/PDL-1 refractory MCC
Mar 25, 2022 6:00 PM — 6:15 PM Westin Seaport Hotel in Boston
Project Event Follow

Peer Insights on the Management of Patients With Cutaneous Squamous Cell Carcinoma

Management Pearls for Advanced CSCC
Mar 25, 2022 12:00 PM — 1:00 PM Online Forum
Project Follow

Peer Insights on the Management of Patients With Cutaneous Squamous Cell Carcinoma

Management Pearls for Advanced CSCC
Mar 18, 2022 4:00 PM — 5:00 PM Online Forum
Project Follow
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Recent Posts

Optimizing Real-World Data Collection: The Lesion Information Electronic Data Capture Instrument

We publish the data dictionary for our Lesion Information data collection instrument
Last updated on Dec 9, 2021 111 min read

Data Quality Improvement in Cancer Registries- Error-Injection Tests

A proposed workflow for monitoring completion of retrospective records in a patient registry hosted on REDCap
Last updated on Jul 23, 2021 9 min read

Optimizing Real-World Data Collection: Genomics Electronic Data Capture Instrument

We publish the data dictionary for our genomics data collection instrument
Last updated on May 9, 2021 4645 min read

FlexDashboards for Clinical and Translational Research

A monograph on how to create Dashboards using R via a package called flexdashboard
Jan 5, 2021 24 min read

A REDCap-to-R Pipeline for Interactive Body Map Visualizations in Cutaneous Oncology

A data science tool for interactive visualizations of skin cancer lesions
Last updated on Sep 4, 2021 950 min read

Communicating CT Research via Website Development with R

This working document is a rough user guide on how to create a website using R via a package called blogdown
Dec 14, 2020 11 min read

Optimizing Real-World Data Collection: Clinical Genomics

Facilitate capture of real-world next-generation genomic data
Last updated on Jan 5, 2021 11 min read

Reference Management in RMarkdown

Integrate your EndNote library into RMarkdown
Last updated on May 9, 2021 4 min read

Tutorial Series on the Instruments of the Merkel Cell Carcinoma Patient Registry: Presentation and Initial Staging

Outlining the development of the “Presentation and Initial Staging Instrument” of the Merkel Cell Carcinoma Patient …
Last updated on Jan 5, 2021 8 min read

Visualizing Tumor Response using Waterfall Charts with R

Visualizing Tumor Response using Waterfall Charts with R
Jan 6, 2021 7 min read
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Past and Current Funding

Project Data Sphere’s Mentoring Award in Oncology, Advanced Analytics and Regulatory Science

Merkel Cell Carcinoma Patient Registry
Last updated on Dec 12, 2019

ECOG ACRIN Paul Carbone, MD Fellowship Award

A Novel JAK1 Inhibitor to Overcome BRAF/MEK Inhibitor Resistance in V600-BRAF Mutant Melanoma
Last updated on Dec 12, 2019

American Skin Association Research Grant

JAK1 Inhibition to Overcome BRAF/MEK Inhibitor Resistance in V600-BRAF Mutant Melanoma
Last updated on Dec 12, 2019

American Diabetes Association Physician Scientist Training Award

Umbilical cord blood stem cells as therapy for Diabetes Mellitus
Last updated on Dec 12, 2019

Support Cancer Research

If you are interested in supporting our research please visit our Donation page at Massachusetts General Hospital by clicking here.

Contact

Clinical Matters:

For clinical questions, please contact the MGH Cancer Center
Telephone: 617-724-5197
Fax: 617-643-1740

Lab Related Matters

The below contact information is for The Miller Lab related matters

Email

  • 617-726-2667
  • 15 Parkman Street, Boston, MA, 02114, United States
  • Enter Bartlett Hall, to Basement, Room 132
  • DM Me