Clinical & Translational Investigators in Skin Cancer

Ongoing Projects, Research and Efforts

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All MCC Registry Clinical Trials Data Science Biomarkers Clinical Educator Real World Data Regulatory Medicine

Clinical Educator

Participating in the education of tomorrow’s clinicians

Real World Data Analysis

Optimizing Real World Data Collection

Clinical Trials for Skin Cancer

Investigating novel therapies for patients with advanced skin cancer

Biomarkers of Response and Resistance to Cancer Therapy

Investigating why patients do or do not respond to cancer therapies

Data Science Tool Development

Developing Data Science tools to facilitate clinical and translational research

Evolving Landscape of Regulatory Medicine

Evaluating the evolving landscape of regulatory medicine in Cutaneous Oncology and Dermatology

Merkel Cell Carcinoma Patient Registry

Developing a multi-institutional Patient Registry.

Meet the Team

Principal Investigator

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David Michael Miller

Medical Oncologist and Dermatologist

Clinical And Translational Research, Advanced Skin Cancer, Data Science, R

Fellows

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Sophia Shalhout

Cutaneous Oncology Research Fellow

Clinical and Biomedical Informatics, Immuno-oncology/Cutaneous Oncology, R/Data Science

Students

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Farees Saqlain

Medical Student

Clinical And Translational Research, Merkel Cell Carcinoma, Squamous Cell Carcinoma

Researchers

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Kayla Wright

Clinical Research Assistant

Biomedical Research, Photography

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Matthew Miller

Clinical Research Assistant

Biomedical Research

Publications

Diagnostic yield of staging brain magnetic resonance imaging is low in Merkel cell carcinoma - A single-institution cohort study

In the JAAD, we provide a real-world assessment of the yield of diagnostic brain MRIs in Merkel Cell Carcinoma.
PDF Project Project Source Document DOI

GENETEX - A GENomics Report TEXt Mining R Package and Shiny Application Designed to Capture Real-World Clinico-Genomic Data

We created GENETEX, an R package and Shiny application for text mining genomic reports from EHR and direct import into REDCap®.
PDF Code Dataset Project Project Video Source Document

Clinical Utility of Cell-free DNA Liquid Biopsies in Merkel Cell Carcinoma

An examination of the clinical utility of liquid biopsies in Merkel Cell Carcinoma.
Project Project

Immunotherapy for Non-Melanoma Skin Cancer

We review the latest trends in cancer care for Non-Melanoma skin cancer.
PDF Project Project Source Document DOI

Evaluation of clinical characteristics and pre-biopsy impressions of primary Merkel cell carcinoma of the skin

A review of prebiopsy clinical DDx of primary cutaneous MCC lesions from a recent, single-institution 5 year cohort.
Project Project

Immune Checkpoint Inhibition in Marjolin Ulcer - A Case Series

We provide a case series in the Journal of Immunotherapy of response to anti-PD1 therapy in Marjolin Ulcer.
Project Source Document DOI

Commentary on Surgical Margins in MCC

We provide commentary on a recent publication in JAMA Derm on margins in MCC.
Source Document

Microsatellitosis in Merkel cell carcinoma - a staging quandary

We provide an analysis in the Dermatology Online Journal of microsatellitosis in a cohort of MCC patients.
Project Source Document

Real-world assessment of response to anti-PD1 therapy in advanced cutaneous squamous cell carcinoma

In the JAAD, we provide a real-world assessment of response to anti-PD1 therapy in advanced cutaneous squamous cell carcinoma.
PDF Project Source Document DOI

A REDCap-Based Operational Tool to Guide Care Coordination in a Multidisciplinary Cutaneous Oncology Clinic

We present A REDCap-Based Operational Tool to Guide Care Coordination in a Multidisciplinary Cutaneous Oncology Clinic
Source Document DOI

Clinical landscape of oncolytic virus research in 2020

We provide an overview of the clinical landscap of oncolytic virus research.
Project Source Document DOI

Metastatic Merkel Cell Carcinoma Masquerading as multiple immune-related Adverse Events

We present a case of MCC masquerading as Multiple Immune-Related Adverse Events
PDF Project Source Document DOI

Regionally Metastatic Merkel Cell Carcinoma Associated with Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis

We present a case of MCC presenting with NMDA Receptor Encephalitis.
PDF Project Source Document DOI

TdT Expression Is a Marker of Better Survival in Merkel Cell Carcinoma, and Expression of B-Cell Markers Is Associated With Merkel Cell Polyomavirus

TdT expression is a potential marker of better survival in Merkel cell carcinoma.
DOI

Evaluation of the fragility of pivotal trials used to support FDA approval for plaque psoriasis

We evaluate the fragility of pivotal trials used to support FDA approval in Plaque Psoriasis.
Project Source Document DOI
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Recent & Upcoming Talks

Generating an Anti-Tumor Response - Immune System Activation for the Treatment of Advanced/Metastatic BCC and cSCC

Pearls for the Management of Advanced NMSC
Oct 8, 2021 3:00 PM — 4:00 PM Online Forum
Project Follow

Squamous Cell Carcinoma - Current Concepts in Management

Pearls on the current concepts in management of SCC
Oct 4, 2021 3:00 PM — 3:30 PM Massachusetts General Hospital
Project Slides Follow

GENETEX - A GENomics Report TEXt Mining R Package to Capture Real-World Clinico-genomic Data

We present an overview of the GENETEX package
Aug 26, 2021 2:33 PM — Oct 4, 2021 2:54 PM Virtual Forum
Project Video Follow

Nonmelanoma Skin Cancers - Who Is in the Waiting Room

Pearls on the current concepts in diagnosis and management of NMSC
Aug 7, 2021 7:00 PM — 8:30 PM JW Marriott
Project Event Follow

Merkel Cell Carcinoma - Current Concepts in Diagnosis and Management

Pearls on the current concepts in diagnosis and management of MCC
Aug 7, 2021 4:30 PM — 5:00 PM American Academy of Dermatology Summer Meeting
Project Slides Follow

Diagnostic Yield of Staging Brain MRI in Merkel Cell Carcinoma

We discuss the utility of brain MRI for the initial staging of MCC
Jul 19, 2021 8:00 PM — 8:30 PM Massachusetts General Hospital Online Forum
Project Follow

Merkel Cell Carcinoma - Current Concepts in Diagnosis and Management

Pearls on the current concepts in diagnosis and management of MCC
Jun 11, 2021 3:00 PM — 3:30 PM Massachusetts General Hospital
Project Slides Follow

eLAB - a Large-Scale Laboratory Integration Informatics Pipeline for Clinical Research

May 17, 2021 8:30 PM — 9:00 PM Virtual Platform
Project Project Project Follow

GENETEX - an NLP R Package for Text Mining Genomic Reports

May 7, 2021 8:00 PM — May 17, 2021 8:30 PM Massachusetts General Hospital Online Forum
Project Project Project Follow

Immune Checkpoint Inhibitor for Cutaneous Squamous Cell Carcinoma

Pearls for the Management of Advanced CSCC
Apr 22, 2021 7:00 PM — Apr 11, 2021 8:00 PM Online Forum
Project Video Follow
See all talks

Recent Posts

Data Quality Improvement in Cancer Registries- Error-Injection Tests

A proposed workflow for monitoring completion of retrospective records in a patient registry hosted on REDCap
Last updated on Jul 23, 2021 9 min read

Optimizing Real-World Data Collection: Genomics Electronic Data Capture Instrument

We publish the data dictionary for our genomics data collection instrument
Last updated on May 9, 2021 4645 min read

FlexDashboards for Clinical and Translational Research

A monograph on how to create Dashboards using R via a package called flexdashboard
Jan 5, 2021 24 min read

A REDCap-to-R Pipeline for Interactive Body Map Visualizations in Cutaneous Oncology

A data science tool for interactive visualizations of skin cancer lesions
Last updated on Sep 4, 2021 950 min read

Communicating CT Research via Website Development with R

This working document is a rough user guide on how to create a website using R via a package called blogdown
Dec 14, 2020 11 min read

Optimizing Real-World Data Collection: Clinical Genomics

Facilitate capture of real-world next-generation genomic data
Last updated on Jan 5, 2021 11 min read

Reference Management in RMarkdown

Integrate your EndNote library into RMarkdown
Last updated on May 9, 2021 4 min read

Tutorial Series on the Instruments of the Merkel Cell Carcinoma Patient Registry: Presentation and Initial Staging

Outlining the development of the “Presentation and Initial Staging Instrument” of the Merkel Cell Carcinoma Patient …
Last updated on Jan 5, 2021 8 min read

Visualizing Tumor Response using Waterfall Charts with R

Visualizing Tumor Response using Waterfall Charts with R
Jan 6, 2021 7 min read

Optimizing Real World Data Collection: Flagging Prospective Records for Future Update

A proposed workflow for flagging prospective records for future updates in a patient registry hosted on REDCap
May 17, 2020 4 min read
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Past and Current Funding

Project Data Sphere’s Mentoring Award in Oncology, Advanced Analytics and Regulatory Science

Merkel Cell Carcinoma Patient Registry
Last updated on Dec 12, 2019

ECOG ACRIN Paul Carbone, MD Fellowship Award

A Novel JAK1 Inhibitor to Overcome BRAF/MEK Inhibitor Resistance in V600-BRAF Mutant Melanoma
Last updated on Dec 12, 2019

American Skin Association Research Grant

JAK1 Inhibition to Overcome BRAF/MEK Inhibitor Resistance in V600-BRAF Mutant Melanoma
Last updated on Dec 12, 2019

American Diabetes Association Physician Scientist Training Award

Umbilical cord blood stem cells as therapy for Diabetes Mellitus
Last updated on Dec 12, 2019

Support Cancer Research

If you are interested in supporting our research please visit our Donation page at Massachusetts General Hospital by clicking here.

Contact

Clinical Matters:

For clinical questions, please contact the MGH Cancer Center
Telephone: 617-724-5197
Fax: 617-643-1740

Lab Related Matters

The below contact information is for The Miller Lab related matters

Email

  • 617-726-2667
  • 15 Parkman Street, Boston, MA, 02114, United States
  • Enter Bartlett Hall, to Basement, Room 132
  • DM Me