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Figure S2. Association of initial AMERK titer and additional measures of tumor burden. Seropositive subjects were stratified based on AJCC 8th edition clinical tumor stage (A) and on greatest primary tumor size (largest size across either clinical, radiographic or pathological measurement) (B). Subjects without a known skin primary were excluded from A and B. In panels C and D, seropositive subjects were stratified based on AJCC 8th edition pathological nodal stage (C) and clinical stage (D). Clinical stage IIA and IIB subjects were binned in panel D. Initial AMERK titer was log-transformed. The initial clinical stage of each subject is color-coded. A non-parametric test (kruskal-wallis) was performed to evaluate differences between these groups.