A Complete Response in cSCC with Ipi/Nivo


David M. Miller, Faulkner-Jones, B. E., Stone, J. R., Drews, R. E.


September 7, 2017


Although most cases of metastatic cutaneous Squamous Cell Carcinoma mCSCC can be cured with local therapy, up to 8,000 deaths occur each year. With no US Food and Drug Administration-approved options available for mcSCC, common approaches include platinum- based chemotherapy and off-label cetuximab. These strategies lack durability, and overall survival for mcSCC is only 10.9 months. Here we report a complete pathologic response after 4 cycles of nivolumab and the antieCTLA-4 antibody, ipilimumab, in a patient with mCSCC.