Date
Dec 3, 2021 7:45 AM — 8:45 AM
Event
Harvard Dermatology Resident Lecture
Location
Massachusetts General Hospital
132 Parkman St., Boston, MA, 02114, United States
TABLE OF CONTENTS
- Understand the current therapeutic landscape for high-risk localized cutaneous melanoma
- Review treatment strategies for high-risk regionally metastatic melanoma
- Discuss management options for patients with metastatic melanoma
Synopsis
- A 71-year-old Male with a history of NMSC presents for follow up to discuss the pathology results of a recent biopsy of a pigmented lesion on his back
Pathology reveals:
- HISTOLOGIC TYPE: Superficial spreading melanoma
- PRECURSOR LESION: Not identified
- MAXIMUM TUMOR THICKNESS: 3.0 mm
- ANATOMIC LEVEL: At least level IV
- ULCERATION: Present
- MITOTIC RATE: 9 per mm2
- LYMPHOVASCULAR INVASION: Present, Foci suspicious for lymphovascular invasion
- METHOD OF DETECTION: Hematoxylin and eosin
- RADIAL GROWTH PHASE: Present
- VERTICAL GROWTH PHASE: Present
- TYPE OF VERTICAL GROWTH: Epithelioid
- MICROSATELLITES: Cannot be assessed
- PERINEURAL INVASION: Cannot be assessed
- TUMOR-INFILTRATING LYMPHOCYTES: Present, nonbrisk
- TUMOR REGRESSION: Absent
- MARGINS: Extending to inked lateral and deep resection margins
Case 1 Clinical Questions:
- What is this patient’s T stage?
- What would be your next steps in work up?
- What would be your surgical plan?
- What additional studies (if any) would you order?
- What would be your surgical plan?
Synopsis
- A 68-year-old Male with a history of HTN, HLD, T3bN1aM0 melanoma presents for follow up to discuss next steps in management.
Relevant Work Up To Date:
- Tumor:
- 3.2 mm thick, ulcerated SSM with 5 mitoses, Right mid back
- 3.2 mm thick, ulcerated SSM with 5 mitoses, Right mid back
- Nodal:
- 1/14 nodes positive for melanoma on sentinel lymph node biopsy
- 1/14 nodes positive for melanoma on sentinel lymph node biopsy
- Imaging:
- No evidence of distant disease
- No evidence of distant disease
- Molecular Testing:
- BRAF p.V600E (c.1799T>A): absent
- BRAF p.V600K (c.1798_1799delGTinsAA): present
- INTERPRETATION: POSITIVE for variant in BRAF.
- BRAF p.V600E (c.1799T>A): absent
Case 2 Clinical Questions:
- What is this patient’s pathological stage?
- What are the therapeutic options for this patient?
Synopsis
- A 58-year-old Female with a history of HTN, HLD, presents with a 3 cm ulcerated pigmented lesion on the right thigh. Physical exam reveals a 6 cm right inguinal mass.
Case 3 Clinical Questions:
- What are your next steps in management?
- If regionally metastatic melanoma is confirmed, what management options are available?
Synopsis
- A 49-year-old Male with a history of pulmonary sarcoidosis presents with BRAF V600 mutated melanoma metastatic to the liver and lungs.
Case 4 Clinical Questions:
- What therapeutic strategies are available for this patient?
- Given the patient’s comorbidities, what would be your first-line treatment strategy?
Interactive Timeline of FDA-Approved Therapies for Melanoma
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David Michael Miller
Medical Oncologist and Dermatologist
My research interests include clinical and translational research in advanced skin cancers.