Pathophysiology - Molecular Genetics of CSCC

  • David Wheeler’s group at Baylor, working with MD Anderson, performed WES on 39 cases of aggressive cSCC to identify driver mutations [^1]
    • They found 61.2 mutations per megabase

1: Pickering et al CCR 2014

Pathophysiology - Molecular Genetics of CSCC

  • Wheelers’ group showed a high frequency of C>T transitions in cSCC [^1]
    • 75% of mutations were C>T (UVB signature) and 5.6% were DNP
    • Similar to Melanoma

1: Pickering et al CCR 2014

AJCC T Stage, 8th Edition

  • Tis
    • In situ carcinoma
  • T1
    • Tumor 2 cm or less in greatest dimension
  • T2
    • Tumor > 2cm in greatest dimension, but <4 cm

AJCC T Stage, 8th Edition

  • T3
    • Tumor ≥4 cm or larger in maximum dimension or minor bone erosion or perineural invasion or deep invasion
  • T4
    • Tumor with gross cortical bone/marrow, skull base invasion and/or skull base foramen invasion