Pathophysiology - Molecular Genetics of CSCC

• David Wheeler’s group at Baylor, working with MD Anderson, performed WES on 39 cases of aggressive cSCC to identify driver mutations [^1]
  
  • They found 61.2 mutations per megabase

1: Pickering et al CCR 2014

Pathophysiology - Molecular Genetics of CSCC

• Wheelers’ group showed a high frequency of C>T transitions in cSCC [^1]
  • 75% of mutations were C>T (UVB signature) and 5.6% were DNP
  • Similar to Melanoma
    

1: Pickering et al CCR 2014

AJCC T Stage, 8th Edition

• Tis
  
  • In situ carcinoma
• T1
  
  • Tumor 2 cm or less in greatest dimension
• T2
  
  • Tumor > 2cm in greatest dimension, but <4 cm
    

AJCC T Stage, 8th Edition

• T3
  
  • Tumor ≥4 cm or larger in maximum dimension or minor bone erosion or perineural invasion or deep invasion
• T4
  
  • Tumor with gross cortical bone/marrow, skull base invasion and/or skull base foramen invasion