Learning Objectives

  • Review basic epidemiology of melanoma
  • Review molecular mechanisms of melanoma
  • Discuss risk factors for melanoma
  • Review how to evaluate and stage patients
  • Overview of management of melanoma

Epidemiology

  • 1:25 Americans will get some kind of melanoma in their lifetime
  • 1:52 Americans will get an invasive melanoma in their lifetime
  • Estimated to be 96,480 newly diagnosed cases of invasive melanoma in the U.S. in 2019
    • 95,830 cases of melanoma in situ
  • Between 9,000-10,000 deaths annually

Melanoma Pathogenesis

Susceptibility to Cutaneous Malignant Melanoma (CMM)

  • CMM1 has been mapped to chromosome 1p36.
  • CMM2 – CDKN2A (9p21)
  • CMM3 – CDK4 (12q14)
  • CMM4 – mapped to chromosome 1p22
  • CMM5 – MC1R (16q24)
  • CMM6 – XRCC3 (14q32)
  • CMM7 – mapped to chromosome 20q11
  • CMM8 – MITF (3p13)
  • CMM9 – TERT (5p15)
  • CMM10 – POT1 (7q31)

Melanoma Management